abstract：:Bronchopulmonary dysplasia (BPD) is a chronic lung disease most commonly seen in premature infants who required mechanical ventilation and oxygen therapy for acute respiratory distress. While advances in neonatal care have resulted in improved survival rates of premature infants, limited progress has been made in redu...

journal_title：Journal of clinical medicine

authors： Davidson LM,Berkelhamer SK

更新日期：2017-01-06 00:00:00

abstract：:Posttraumatic stress disorder (PTSD) is a chronic psychological disorder that can develop after exposure to a traumatic event. This review summarizes the literature on the epidemiology, assessment, and treatment of PTSD. We provide a review of the characteristics of PTSD along with associated risk factors, and describ...

journal_title：Journal of clinical medicine

authors： Lancaster CL,Teeters JB,Gros DF,Back SE

更新日期：2016-11-22 00:00:00

abstract：:The aim of this paper was to provide insights into alcohol misuse within UK veterans to inform as to whether their presentations differ from the general public. This was done by exploring differences in the severity of alcohol misuse between UK veterans and the general public admitted to a general NHS hospital over an...

journal_title：Journal of clinical medicine

authors： Murphy D,Palmer E,Westwood G,Busuttil W,Greenberg N

更新日期：2016-11-02 00:00:00

abstract：:The authors wish to make the following corrections to this paper [1]:[...]. ...

journal_title：Journal of clinical medicine

authors： Ono S,Lam S,Nagahara M,Hoon DS

更新日期：2016-09-12 00:00:00

abstract：:Pulmonary hypertension (PH) due to chronic respiratory disease and/or hypoxia is classified as World Health Organization (WHO) Group III pulmonary hypertension. The patients most commonly encountered in clinical practice with group III PH include those with chronic obstructive lung disease (COPD), diffuse parenchymal ...

journal_title：Journal of clinical medicine

authors： Fein DG,Zaidi AN,Sulica R

更新日期：2016-08-26 00:00:00

abstract：BACKGROUND:Ghrelin is a 28-amino acid peptide with an orexigenic property, which is predominantly produced by the stomach. Acylated ghrelin is the active form of this hormone. Obestatin is a 23-amino acid peptide which is produced by post-translational modification of a protein precursor that also produces ghrelin. Obe...

journal_title：Journal of clinical medicine

authors： Razzaghy-Azar M,Nourbakhsh M,Pourmoteabed A,Nourbakhsh M,Ilbeigi D,Khosravi M

更新日期：2016-06-23 00:00:00

abstract：:A 37 year-old man presented to the Emergency Department (ED) with new onset seizure and fall from standing.[...]. ...

journal_title：Journal of clinical medicine

authors： Minckler MR,Curry M,Mosier JM

更新日期：2016-04-12 00:00:00

abstract：:microRNAs (miRNAs) are small non-coding RNAs that regulate gene expression by either blocking translation or inducing degradation of target mRNA. miRNAs play essential roles in diverse biological and pathological processes, including development of hepatic fibrosis. Hepatic stellate cells (HSCs) play a central role in...

journal_title：Journal of clinical medicine

authors： Kitano M,Bloomston PM

更新日期：2016-03-16 00:00:00

abstract：:Intravenous lipid emulsions are an essential component of parenteral nutrition regimens. Originally employed as an efficient non-glucose energy source to reduce the adverse effects of high glucose intake and provide essential fatty acids, lipid emulsions have assumed a larger therapeutic role due to research demonstra...

journal_title：Journal of clinical medicine

authors： Klek S

更新日期：2016-03-07 00:00:00

abstract：:Traumatic brain injury is not a discrete event but an unfolding sequence of damage to the central nervous system. Not only the acute phase but also the subacute and chronic period after injury, i.e., during inpatient rehabilitation, is characterized by multiple neurotransmitter alterations, cellular dysfunction, and m...

journal_title：Journal of clinical medicine

authors： Renner CI

更新日期：2015-09-22 00:00:00

abstract：:Diabetic nephropathy patients traditionally show significant macroalbuminuria prior to the development of renal impairment. However, this clinical paradigm has recently been questioned. Epidemiological surveys confirm that chronic kidney disease (CKD) diagnosed by a low glomerular filtration rate (GFR) is more common ...

journal_title：Journal of clinical medicine

authors： Robles NR,Villa J,Gallego RH

更新日期：2015-09-07 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is a poor-prognosis cancer due to its high rate of recurrence. microRNAs (miRNAs) are a class of small non-coding RNA molecules that affect crucial processes in cancer development. The objective of this study is to identify the role of miRNAs in patient bone marrow (BM) and explore the f...

journal_title：Journal of clinical medicine

authors： Sugimachi K,Sakimura S,Tomokuni A,Uchi R,Hirata H,Komatsu H,Shinden Y,Iguchi T,Eguchi H,Masuda T,Morita K,Shirabe K,Eguchi H,Maehara Y,Mori M,Mimori K

更新日期：2015-08-14 00:00:00

abstract：:Creatinine is produced in muscle metabolism as the end-product of creatine phosphate and is subsequently excreted principally by way of the kidneys, predominantly by glomerular filtration. Blood creatinine assays constitute the most common clinically relevant measure of renal function. The use of individual patient-le...

journal_title：Journal of clinical medicine

authors： Onuigbo MA,Agbasi N

更新日期：2015-06-26 00:00:00

abstract：:Diabetic nephropathy (DN) often develops in patients suffering from type 1 or type 2 diabetes mellitus. DN is characterized by renal injury resulting in proteinuria. Neuropilin-1 (NRP-1) is a single-pass transmembrane receptor protein devoid of enzymatic activity. Its large extracellular tail is structured in several ...

journal_title：Journal of clinical medicine

authors： Bondeva T,Wolf G

更新日期：2015-06-17 00:00:00

abstract：:Multidisciplinary interventions have been developed for patients with atopic dermatitis (AD) and their families, with the aim of improving outcomes such as disease control, adherence, and quality of life. We reviewed the content of different multidisciplinary approaches to intervention for AD and evidence for their im...

journal_title：Journal of clinical medicine

authors： Spielman SC,LeBovidge JS,Timmons KG,Schneider LC

更新日期：2015-05-21 00:00:00

abstract：:Atopic eczema (AE) in the elderly is gradually increasing and has been added to the classification of AE in recent years. This investigation retrospectively analyzed 60 patients with elderly AE. Among the clinical characteristics, a male predominance, existence of several patterns of onset and clinical course, and ass...

journal_title：Journal of clinical medicine

authors： Tanei R

更新日期：2015-05-18 00:00:00

abstract：:Human papillomavirus (HPV) is the most common sexually transmitted disease. Via infection of the basal epithelial cells, HPV causes numerous malignancies and noncancerous cutaneous manifestations. Noncancerous cutaneous manifestations of HPV, including common, plantar, plane, and anogenital warts, are among the most c...

journal_title：Journal of clinical medicine

authors： Kollipara R,Ekhlassi E,Downing C,Guidry J,Lee M,Tyring SK

更新日期：2015-04-24 00:00:00

abstract：:Since the discovery of the causal association between human papillomavirus (HPV) and cervical cancer, efforts to develop an effective prophylactic vaccine to prevent high-risk HPV infections have been at the forefront of modern medical research. HPV causes 530,000 cervical cancer cases worldwide, which is the second m...

journal_title：Journal of clinical medicine

authors： Kash N,Lee MA,Kollipara R,Downing C,Guidry J,Tyring SK

更新日期：2015-04-03 00:00:00

abstract：:The application of biomarkers in medicine is evolving. Biomarkers do not only give us a better understanding of pathogenesis, but also increase treatment efficacy and safety, further enabling more precise clinical care. This paper focuses on the current use of biomarkers in atopic dermatitis, new developments and futu...

journal_title：Journal of clinical medicine

authors： Thijs JL,van Seggelen W,Bruijnzeel-Koomen C,de Bruin-Weller M,Hijnen D

更新日期：2015-03-16 00:00:00

abstract：:Age-related macular degeneration (AMD) is the most common cause of irreversible visual impairment in older populations in industrialized nations. AMD is a late-onset deterioration of photoreceptors and retinal pigment epithelium in the central retina caused by various environmental and genetic factors. Great strides i...

journal_title：Journal of clinical medicine

authors： Yonekawa Y,Miller JW,Kim IK

更新日期：2015-02-12 00:00:00

abstract：:Most human papillomavirus (HPV) antiviral strategies have focused upon inhibiting viral DNA replication, but it is increasingly apparent that viral DNA levels can be chemically controlled by approaches that promote its instability. HPVs and other DNA viruses have a tenuous relationship with their hosts. They must repl...

journal_title：Journal of clinical medicine

authors： Fisher C

更新日期：2015-01-01 00:00:00

abstract：:Hyponatremia is common in cirrhosis. It mostly occurs in an advanced stage of the disease and is associated with complications and increased mortality. Either hypovolemic or, more commonly, hypervolemic hyponatremia can be seen in cirrhosis. Impaired renal sodium handling due to renal hypoperfusion and increased argin...

journal_title：Journal of clinical medicine

authors： Bernardi M,Ricci CS,Santi L

更新日期：2014-12-31 00:00:00

abstract：:The future hope of generated induced pluripotent stem cells (iPS cells) from Alzheimer's disease patients is multifold. Firstly, they may help to uncover novel mechanisms of the disease, which could lead to the development of new and unprecedented drugs for patients and secondly, they could also be directly used for s...

journal_title：Journal of clinical medicine

authors： Freude K,Pires C,Hyttel P,Hall VJ

更新日期：2014-12-12 00:00:00

abstract：:Healthcare systems in the developed world are struggling with the demand of emergency room presentations; the study of the factors driving such demand is of fundamental importance. From a database of all emergency medical admissions (66,933 episodes in 36,271 patients) to St James' Hospital, Dublin, Ireland, over 12 y...

journal_title：Journal of clinical medicine

authors： Conway R,Byrne D,O'Riordan D,Silke B

更新日期：2014-10-29 00:00:00

abstract：:Tens of millions of patients are affected by liver disease worldwide. Many of these patients can benefit from cell therapy involving living metabolically active cells, either by treatment of their liver disease, or by prevention of their disease phenotype. Cell therapies, including hepatocyte transplantation and bioar...

journal_title：Journal of clinical medicine

authors： Yu Y,Wang X,Nyberg SL

更新日期：2014-09-05 00:00:00

abstract：:This report describes the trends of chorionic villus sampling (CVS) referred for prenatal genetic diagnosis in the past two and a half decades in a Portuguese Center. Our cohort of 491 CVS was mostly performed by the transcervical method at the 12th gestational week. Data collected within the framework of this study r...

journal_title：Journal of clinical medicine

authors： Jorge P,Mota-Freitas MM,Santos R,Silva ML,Soares G,Fortuna AM

更新日期：2014-07-24 00:00:00

abstract：:Recent advances in molecular genetic technologies have facilitated non-invasive prenatal testing (NIPT) through the analysis of cell-free fetal DNA in maternal plasma. NIPT can be used to identify monogenic disorders including the identification of autosomal recessive disorders where the maternally inherited mutation ...

journal_title：Journal of clinical medicine

authors： Benn P

更新日期：2014-05-21 00:00:00

abstract：:Reprogramming somatic cells to induced pluripotent stem cells (iPSCs) or direct reprogramming to desired cell types are powerful and new in vitro methods for the study of human disease, cell replacement therapy, and drug development. Both methods to reprogram cells are unconstrained by the ethical and social questions...

journal_title：Journal of clinical medicine

authors： Palomo AB,Lucas M,Dilley RJ,McLenachan S,Chen FK,Requena J,Sal MF,Lucas A,Alvarez I,Jaraquemada D,Edel MJ

更新日期：2014-04-04 00:00:00

abstract：:Pediatric bipolar disorder (BD) rates have notably increased over the past three decades. Given the significant morbidity and mortality associated with BD, efforts are needed to identify factors useful in earlier detection to help address this serious public health concern. Sleep is particularly important to consider ...

journal_title：Journal of clinical medicine

authors： Kim KL,Weissman AB,Puzia ME,Cushman GK,Seymour KE,Wegbreit E,Carskadon MA,Dickstein DP

更新日期：2014-03-11 00:00:00

abstract：:Prolonged oligohydramnios following extreme preterm prelabour rupture of membranes (EPPROM) is traditionally associated with a high morbidity and mortality to both the mother and the baby. The clinical maternal evaluation and fetal ultrasound assessment may provide important prognostic information for the clinicians a...

journal_title：Journal of clinical medicine

authors： Engemise S,Thompson F,Davies W

更新日期：2014-01-09 00:00:00

abstract：:For a long time, the stem cell regenerative paradigm has been based on the assumption that progenitor cells play a critical role in tissue repair by means of their plasticity and differentiation potential. However, recent works suggest that the mechanism underlying the benefits of stem cell transplantation might relat...

journal_title：Journal of clinical medicine

authors： Bollini S,Gentili C,Tasso R,Cancedda R

更新日期：2013-12-17 00:00:00

abstract：UNLABELLED:The objective of this study was to evaluate the correlation between multiple cardiovascular risk factors (MCRFs) and circulating mononuclear cells (CMCs) in asymptomatic coronary artery disease patients. DESIGN AND METHODS:126 subjects (54 male), aged 48 to 62 years, with asymptomatic coronary artery diseas...

journal_title：Journal of clinical medicine

authors： Berezin AE,Kremzer AA

更新日期：2013-07-30 00:00:00